Bonito is a type of fish that belong to the mackerel and tuna family and is traditionally eaten in Japan. Researchers in Japan have discovered a patented process to separate specific, active bonito peptides which demonstrates a lowering effect on blood pressure in humans and animals.
Bonito peptides offer natural and safe blood pressure support for persons with Stage I hypertension (systolic blood pressure: 145-159; diastolic blood pressure: 90-99 mmHg) or pre hypertension (systolic pressure: 120-139 mmHg; diastolic pressure: 80-89 mmHg).
This fishy, secret ingredient found in plenty of Japanese culinary masterpieces has proved to be an effective method of controlling high blood pressure. Bonito Peptide work by reducing the body’s production of angiotensin II that is known to increase blood pressure. Angiotensin II is mainly secreted by the liver and is one of the chemical messengers responsible for the constriction of blood vessels. When high blood pressure is an issue, a reduction in the production of angiotensin II has thought to bringing down blood pressure.
A therapeutic dosage of Bonito peptide is usually taken about 1.5 to 3 grams per day, which would require a lot of Japanese fermented soybean paste to be obtained from a food sources alone. With bonito peptide supplements, many people have shown significant drops in blood pressure, and some in as little 7 days.
Bonito peptides have proved to prevent the activity of ACE (angiotensin-converting enzyme). ACE speeds up the production of angiotensin II, which is a potent compound that is responsible for the narrowing of the blood vessels. When in excess, it could lead to harmful effects such as blot clot formation, increased oxidative stress and local arterial damage. Because of its physiological effects, angiotensin II could have a connection with the development of high blood pressure, diabetes related nerve damage and in vascular diseases like atherosclerosis.
Researchers in Japan have discovered 9 active specific peptides present in dried bonito fish. Some of enzyme properties enable the mixture of bonito peptide have a continuous lowering effect on blood pressures in mild and borderline hypertensive persons, without resulting in a sudden rise in blood pressure after omitting a dosage.
Three human clinical trials have been conducted successfully using bonito peptides with respect to mild or borderline hypertension. Available data has shown a significant reduction in blood pressure with a decrease of 7mmHg in diastolic blood pressure and 10 mmHg in systolic blood pressure after use for several weeks. In a recent research, scientists made use of an optimized mixture of bonito peptide of 1.5g every day.
Clinical research suggest that bonito peptides are about 64% efficient in lowering blood pressure in mild and borderline hypertensive patients. Within this short clinical experiment, there were no side effects reported. This suggests that bonito peptide had no effect on subjects with normal range blood pressures.